Relationship between aldehyde oxidase activity and biological activity of cyclophosphamide
نویسندگان
چکیده
منابع مشابه
antioxidant and antimicrobial activity of allium jesdianum extract
چکیده بررسی فعالیت ضد اکسیدانی و ضدمیکروبی عصاره گیاه بن سرخ (allium jesdianum) به کوشش: زهرا مقیمی هدف از این تحقیق بررسی میزان ترکیبات فنولی کل، ترکیبات فلاوونوئیدی کل، فعالیت ضداکسیدانی و ضدمیکروبی عصاره ی گیاه تازه و خشک بن سرخ بود. استخراج عصاره به روش های غوطه وری، استفاده از همزن مغناطیسی، دستگاه مایکروویو، امواج فراصوت و گرمادهی مقاومتی و با استفاده از متانول، اتانول و آب به عنوا...
Aldehyde oxidase activity in fresh human skin.
Human aldehyde oxidase (AO) is a molybdoflavoenzyme that commonly oxidizes azaheterocycles in therapeutic drugs. Although high metabolic clearance by AO resulted in several drug failures, existing in vitro-in vivo correlations are often poor and the extrahepatic role of AO practically unknown. This study investigated enzymatic activity of AO in fresh human skin, the largest organ of the body, f...
متن کاملRole of aldehyde dehydrogenase in the metabolism-dependent biological activity of cyclophosphamide.
It has been proposed that cytosolic aldehyde dehydrogenase, measured with acetaldehyde as the substrate, is involved in the in vitro and in vivo detoxification of activated cyclophosphamide (CP) metabolites. Higher levels of this enzyme in some normal tissues, such as liver and kidney, are believed to protect these tissues against the toxic effects of CP, whereas relatively lower levels of this...
متن کاملRelationship between structure and biological activity of novel R106 analogs.
The retro-aldol reaction at residue 8 of R106-1 produced a chemical handle, in the form of a sarcosine residue, that was amenable to classical aldol alkylation conditions. In vitro assay of several new hydroxylated analogs have shown that L isomers exhibit more potent antifungal activity than D isomers. However, all analogs exhibited a significant decrease in activity against Cryptococcus neofo...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1974
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)32256-5